PROTECTIVE EFFECT OF PBC 140 BEAN EXTRACT ON THE SUPPRESSION OF MATRIX METALLOPROTEINASE-1 (MMP-1) IN HUMAN DERMAL FIBROBLASTS
Authors: Norliza, A. W., Russly, A. R. and Roslina, M. S.
Journal Issue: Malaysian Cocoa Journal, Volume 13(2)/2021
Keywords: PBC 140, CBE, HDFa, MMP-1, skin photoageing
Published On: 1/11/2021
Abstract
Excess exposure to solar ultraviolet (UV) irradiation that often leads to decreases of procollagen production and subsequent breakdown of collagen fibers with regard to skin photoageing, are often due to overexpression of matrix metalloproteinases (MMPs). Although several evidences have been reported pertaining to cocoa intake in the improvement of skin health, molecular mechanisms responsible for the beneficial effects of PBC 140 cocoa bean extract (CBE) on the inhibition of MMP-1 expression in extracted ribonucleic acid of human dermal fibroblasts, adult (HDFa), have not yet thoroughly investigated. In this study, reduction of MMP-1 expression of the CBE at 5x102 and 1x103 g/mL, by 9.34- and 25-folds relative to the calibrator, respectively, have verified its significant (p<0.05) photoprotective effect for skin anti-ageing. The results demonstrate that CBE of PBC 140 inhibits MMP-1 expression, suggesting that the extract could be potentially used in the prevention of skin ageing through MMP-1 inhibition, thus dermal matrix can be protected that leads to overall reduction in wrinkle formation. From these findings, further researches have been proposed in the development of Malaysian PBC 140 bean extract as a potential active material for cosmeceutical as well as nutraceutical benefits due to the encouraging results in the suppression of MMP-1.